A Common Test to Screen for Stroke Risk Is Under Review; Health panel takes a new look at carotid-artery ultrasounds, which can produce false positive results

September 8, 2013, 5:22 p.m. ET

A Common Test to Screen for Stroke Risk Is Under Review

Health panel takes a new look at carotid-artery ultrasounds, which can produce false positive results.


After a career driving custom buses for touring rock bands, Ken Goins felt like he was in good shape to enjoy retirement, having lost weight and quit smoking years earlier following a bypass operation at age 50. But on his 69th birthday, an ultrasound test showed an 85% blockage in his left carotid artery, one of the two large blood vessels in the neck that supply blood to the brain and can become clogged with cholesterol. A vascular surgeon performed a carotid endarterectomy—a procedure to remove plaque and restore normal blood flow—to lower the risk of stroke from a blood clot or piece of plaque that can get stuck in a smaller artery in the brain.Mr. Goins, now 70, is one of a growing number of older Americans undergoing carotid-artery screening to detect such blockages, many of them through heart and vascular screening programs that offer a package of tests for one relatively low fee. (Medicare and insurers typically don’t cover such screenings.)

Millions Screened

Mr. Goins, who lives in Flat Rock, N.C., says his local Elks chapter was sponsoring a mobile program from Life Line Screening of Independence, Ohio: five tests, including carotid-artery screening, for $139. (The cost is typically $149.)

Over the past decade, Life Line has screened more than eight million people, at an average age of 62; 93% had one or more risk factors, and 8% had a moderate to serious abnormal finding.

But the use of carotid-artery screening has been highly controversial, in large part because studies show the ultrasound tests have only moderate sensitivity and can produce false-positive results. Follow-up often leads to more sensitive tests that can actually have adverse effects on the patient; in some cases, people with false-positive test results may end up getting unnecessary invasive surgery, according to the U.S. Preventive Services Task Force, which issued a recommendation in 2007 against screening patients without symptoms of disease.

The task force is now reviewing that recommendation as part of its efforts to consider new evidence every five years, according to Michael LeFevre, co-vice chairman of the task force and a professor at the University of Missouri School of Medicine. Dr. LeFevre says the concern isn’t that the ultrasound itself is dangerous, but rather that it can lead to “a cascade of events” that “do more harm than good.”

In some cases, Dr. LeFevre says, patients may receive an angiogram to confirm findings of the ultrasound, and the dye used in that test can put them at risk of a stroke. Carotid surgery itself is associated with a 3% rate of stroke or death within 30 days.

Follow-Up Risks

An important question to be answered by the review is whether there is a “subset” of patients who can be identified as at high enough risk that an ultrasound can help define who needs to go on to more tests and treatments, Dr. LeFevre says. In this way, he notes, “we are not taking people who never had likelihood and causing a stroke.”

Andrew Manganaro, Life Line’s chief medical officer, says that the data used by the task force are outdated, and that angiograms with large amounts of dye are no longer commonly performed. In comments for the task-force review, Life Line said a positive test in one of its screenings would generally lead to a second ultrasound, not directly to surgery. Patients receive a copy of their test results, and the next step is up to their family doctor, Dr. Manganaro says.

Conservative Treatment

Most patients who have a blockage don’t go on to surgery, Dr. Manganaro adds. Rather, they are managed with drug therapy and lifestyle changes. To treat the condition, though, it first needs to be detected.

Some groups advise screening for selected populations. The Society for Vascular Surgery, for example, recommends carotid-artery ultrasounds for those 55 or older with risk factors such as high blood pressure, diabetes, smoking or known cardiovascular disease.

Mr. Goins believes the screening and the subsequent surgery saved him from a stroke. After the procedure, he told his wife, “This is the best birthday present anyone could receive, which is their life.”

Ms. Landro is a Wall Street Journal assistant managing editor and writes the Informed Patient column. She can be reached at encore@wsj.com.

About bambooinnovator
Kee Koon Boon (“KB”) is the co-founder and director of HERO Investment Management which provides specialized fund management and investment advisory services to the ARCHEA Asia HERO Innovators Fund (www.heroinnovator.com), the only Asian SMID-cap tech-focused fund in the industry. KB is an internationally featured investor rooted in the principles of value investing for over a decade as a fund manager and analyst in the Asian capital markets who started his career at a boutique hedge fund in Singapore where he was with the firm since 2002 and was also part of the core investment committee in significantly outperforming the index in the 10-year-plus-old flagship Asian fund. He was also the portfolio manager for Asia-Pacific equities at Korea’s largest mutual fund company. Prior to setting up the H.E.R.O. Innovators Fund, KB was the Chief Investment Officer & CEO of a Singapore Registered Fund Management Company (RFMC) where he is responsible for listed Asian equity investments. KB had taught accounting at the Singapore Management University (SMU) as a faculty member and also pioneered the 15-week course on Accounting Fraud in Asia as an official module at SMU. KB remains grateful and honored to be invited by Singapore’s financial regulator Monetary Authority of Singapore (MAS) to present to their top management team about implementing a world’s first fact-based forward-looking fraud detection framework to bring about benefits for the capital markets in Singapore and for the public and investment community. KB also served the community in sharing his insights in writing articles about value investing and corporate governance in the media that include Business Times, Straits Times, Jakarta Post, Manual of Ideas, Investopedia, TedXWallStreet. He had also presented in top investment, banking and finance conferences in America, Italy, Sydney, Cape Town, HK, China. He has trained CEOs, entrepreneurs, CFOs, management executives in business strategy & business model innovation in Singapore, HK and China.

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