Scientists find possible new way of fighting high blood pressure

Scientists find possible new way of fighting high blood pressure

11:01am EDT

By Kate Kelland

LONDON (Reuters) – Scientists experimenting with rats have found that de-activating certain nerves in the neck can effectively treat high blood pressure – a discovery that could be an advance in tackling one of the world’s biggest silent killers. Researchers at Britain’s Bristol University found that in rats with high blood pressure, when they removed nerve links between the brain and the carotid body – a nodule about the size of a grain of rice on the side of each carotid artery – the animals’ blood pressure fell and remained low.The researchers results, published in the journal Nature Communications on Tuesday, have already led the team on to conduct a small human trial of the technique, with results expected at the end of this year.

Hypertension, or high blood pressure, is referred to by the World Health Organization as one of the world’s biggest silent killers because most people who have it can’t feel or see it.

It affects around one in three people worldwide and can cause stroke, heart attacks and kidney failure.

After diagnosis, treatment of high blood pressure needs to be lifelong and many patients are able to manage their condition with anti-hypertension drugs. But experts say that for around 1 in 50 of them, medication does not help.

Julian Paton, who led this latest study at Bristol’s school of physiology and pharmacology, said while scientists already knew of a link between the carotid organs and hypertension, until now they “had absolutely no idea that they contributed so massively to the generation of high blood pressure.”

Tim Chico, as consultant cardiologist at the University of Sheffield who was not directly involved in the research, described the technique as “exciting and innovative” but cautioned that more work was needed to assess its effectiveness and safety before it could be considered for use in patients.

Normally, Paton explained, the carotid body acts to regulate the amount of oxygen and carbon dioxide in the blood.

It is stimulated when oxygen levels fall in the blood – such as when someone is holding their breath. This then causes a dramatic increase in breathing and blood pressure until blood oxygen levels are restored.

Having established that this response comes about through a nerve connection between the carotid body and the brain, Paton’s team decided to block the nerve endings in the neck and found that it swiftly brought their blood pressure down.

Jeremy Pearson, associate medical director at the British Heart Foundation, which part-funded this latest research, said all eyes are now on the human trial aiming to find out whether the treatment might work in people with high blood pressure who don’t get better with current drugs.

Tony Heagerty, a professor of medicine at Manchester University who was not involved in the study, said it was an interesting development which could “potentially avoid the use of drugs which have to be taken on a daily basis for many years.”

About bambooinnovator
Kee Koon Boon (“KB”) is the co-founder and director of HERO Investment Management which provides specialized fund management and investment advisory services to the ARCHEA Asia HERO Innovators Fund (www.heroinnovator.com), the only Asian SMID-cap tech-focused fund in the industry. KB is an internationally featured investor rooted in the principles of value investing for over a decade as a fund manager and analyst in the Asian capital markets who started his career at a boutique hedge fund in Singapore where he was with the firm since 2002 and was also part of the core investment committee in significantly outperforming the index in the 10-year-plus-old flagship Asian fund. He was also the portfolio manager for Asia-Pacific equities at Korea’s largest mutual fund company. Prior to setting up the H.E.R.O. Innovators Fund, KB was the Chief Investment Officer & CEO of a Singapore Registered Fund Management Company (RFMC) where he is responsible for listed Asian equity investments. KB had taught accounting at the Singapore Management University (SMU) as a faculty member and also pioneered the 15-week course on Accounting Fraud in Asia as an official module at SMU. KB remains grateful and honored to be invited by Singapore’s financial regulator Monetary Authority of Singapore (MAS) to present to their top management team about implementing a world’s first fact-based forward-looking fraud detection framework to bring about benefits for the capital markets in Singapore and for the public and investment community. KB also served the community in sharing his insights in writing articles about value investing and corporate governance in the media that include Business Times, Straits Times, Jakarta Post, Manual of Ideas, Investopedia, TedXWallStreet. He had also presented in top investment, banking and finance conferences in America, Italy, Sydney, Cape Town, HK, China. He has trained CEOs, entrepreneurs, CFOs, management executives in business strategy & business model innovation in Singapore, HK and China.

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