Stroke prevention drug found to slow mild dementia

Stroke prevention drug found to slow mild dementia


FEB 27, 2014

OSAKA – Researchers have found that a drug used in the prevention of strokes, cilostazol, is effective in slowing the progression of mild dementia, according to a study published Thursday in the U.S. online science journal Plos One.

The team including Masafumi Ihara, chief physician at the National Cerebral and Cardiovascular Center, said that the drug seems to improve the excretion of waste products in the brain that cause dementia.

Four million people in Japan are believed to have mild cognitive impairment (MCI), and a half of them are set to develop dementia-related illnesses such as Alzheimer’s disease within five years, according to one estimate.

The study was based on an analysis of the medical records of Alzheimer’s patients who were given the drug and those who were not administered it.

The team plans to start clinical research with MCI patients this fall with Mie University, Kyoto University and Kobe University.

Dementia patients often develop vascular diseases, and the team has noted that cilostazol enlarges the blood vessels to improve blood flow in the brain.

The team carried out a survey to check whether taking cilostazol in addition to dementia medications made any difference in the decline of cognitive functions in Alzheimer’s patients, assigning scores on a 30-point scale.

Among those who can barely manage a social life, 36 people who were not taking cilostazol saw their scores fall by an average of 2.2 points over a year, compared with a 0.5 drop in 34 people who were taking the medicine. Improvements were even reported in some areas, but no effect was seen in patients with advanced conditions, the study said.

The team has discovered that cilostazol promotes excretion of waste products in the brain in mice with symptoms of Alzheimer’s disease.

Other participants in the latest study include a research institute at the Kobe-based Foundation for Biomedical Research and Innovation.


About bambooinnovator
Kee Koon Boon (“KB”) is the co-founder and director of HERO Investment Management which provides specialized fund management and investment advisory services to the ARCHEA Asia HERO Innovators Fund (, the only Asian SMID-cap tech-focused fund in the industry. KB is an internationally featured investor rooted in the principles of value investing for over a decade as a fund manager and analyst in the Asian capital markets who started his career at a boutique hedge fund in Singapore where he was with the firm since 2002 and was also part of the core investment committee in significantly outperforming the index in the 10-year-plus-old flagship Asian fund. He was also the portfolio manager for Asia-Pacific equities at Korea’s largest mutual fund company. Prior to setting up the H.E.R.O. Innovators Fund, KB was the Chief Investment Officer & CEO of a Singapore Registered Fund Management Company (RFMC) where he is responsible for listed Asian equity investments. KB had taught accounting at the Singapore Management University (SMU) as a faculty member and also pioneered the 15-week course on Accounting Fraud in Asia as an official module at SMU. KB remains grateful and honored to be invited by Singapore’s financial regulator Monetary Authority of Singapore (MAS) to present to their top management team about implementing a world’s first fact-based forward-looking fraud detection framework to bring about benefits for the capital markets in Singapore and for the public and investment community. KB also served the community in sharing his insights in writing articles about value investing and corporate governance in the media that include Business Times, Straits Times, Jakarta Post, Manual of Ideas, Investopedia, TedXWallStreet. He had also presented in top investment, banking and finance conferences in America, Italy, Sydney, Cape Town, HK, China. He has trained CEOs, entrepreneurs, CFOs, management executives in business strategy & business model innovation in Singapore, HK and China.

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